A simple and efficient procedure for the synthesis of benzimidazoles using air as the oxidant

被引：251

作者：

Lin, SN ^{[1
]}

Yang, L ^{[1
]}

机构：

[1] Merck Res Labs, Rahway, NJ 07065 USA

来源：

TETRAHEDRON LETTERS | 2005年 / 46卷 / 25期

关键词：

benzimidazoles; heterocycle; aldehydes; air oxidation; simple procedure; mild conditions; green chemistry;

D O I：

10.1016/j.tetlet.2005.04.101

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Direct one-step synthesis of various benzimidazoles from phenylenediamines and aldehydes is described using air as the oxidant. The salient features of this method include a simple procedure. mild conditions, 110 Coupling agents or commercial oxidants/additives used. no waste produced (only by-product being water), easy purification, and high generality. (c) 2005 Elsevier Ltd. All rights reserved.

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页码：4315 / 4319

页数：5

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