Human serum haptoglobin is toxic to Plasmodium falciparum in vitro

被引：18

作者：

Imrie, H

Ferguson, DJP

Day, KP

机构：

[1] Univ Oxford, Dept Zool, Oxford OX1 3SY, England

[2] John Radcliffe Hosp, Dept Pathol & Bacteriol, Oxford OX3 9DU, England

来源：

MOLECULAR AND BIOCHEMICAL PARASITOLOGY | 2004年 / 133卷 / 01期

基金：

英国惠康基金;

关键词：

haptoglobin; Plasmodium falciparum; acute phase proteins;

D O I：

10.1016/j.molbiopara.2003.07.007

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Innate immune responses are important in the control of malaria, particularly in those who have not yet mounted an effective adaptive response. Here we report that the human serum acute phase protein, haptoglobin, is toxic to Plasmodium falciparum cultured in vitro. This effect is phenotype dependent and occurs during the trophozoite phase of the asexual life cycle. We propose that the increased levels of haptoglobin seen in the acute phase response may be protective against malaria in humans. (C) 2003 Elsevier B.V. All rights reserved.

引用

收藏

页码：93 / 98

页数：6

相关论文

共 27 条

[1] Haptoglobin directly affects T cells and suppresses T helper cell type 2 cytokine release [J].

Arredouani, M ;

Matthijs, P ;

Van Hoeyveld, E ;

Kasran, A ;

Baumann, H ;

Ceuppens, JL ;

Stevens, E .

IMMUNOLOGY, 2003, 108 (02) :144-151

[2] Haptoglobin genotypes are not associated with resistance to severe malaria in The Gambia [J].

Aucan, C ;

Walley, AJ ;

Greenwood, BM ;

Hill, AVS .

TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE, 2002, 96 (03) :327-328

[3] PURIFICATION OF HAPTOGLOBIN AND ITS EFFECTS ON LYMPHOCYTE AND ALVEOLAR MACROPHAGE RESPONSES [J].

BASELER, MW ;

BURRELL, R .

INFLAMMATION, 1983, 7 (04) :387-400

[4] Pfsbp 1, a Maurer's cleft Plasmodium falciparum protein, is associated with the erythrocyte skeleton [J].

Blisnick, T ;

Eugenia, M ;

Betoulle, M ;

Barale, JC ;

Uzureau, P ;

Berry, L ;

Desroses, S ;

Fujioka, H ;

Mattei, D ;

Breton, CB .

MOLECULAR AND BIOCHEMICAL PARASITOLOGY, 2000, 111 (01) :107-121

[5] Malaria as a possible evolutionary cause of allergy [J].

Bottini, N ;

Ronchetti, MP ;

Gloria-Bottini, F ;

Fontana, L .

ALLERGY, 1999, 54 (02) :188-189

[6] Translocation of endotoxin and acute-phase proteins in malleolar fractures [J].

Buttenschoen, K ;

Fleischmann, W ;

Haupt, U ;

Kinzl, L ;

Buttenschoen, DC .

JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE, 2000, 48 (02) :241-245

[7] IDENTIFICATION OF HAPTOGLOBIN AS AN ANGIOGENIC FACTOR IN SERA FROM PATIENTS WITH SYSTEMIC VASCULITIS [J].

CID, MC ;

GRANT, DS ;

HOFFMAN, GS ;

AUERBACH, R ;

FAUCI, AS ;

KLEINMAN, HK .

JOURNAL OF CLINICAL INVESTIGATION, 1993, 91 (03) :977-985

[8] GENES NECESSARY FOR EXPRESSION OF A VIRULENCE DETERMINANT AND FOR TRANSMISSION OF PLASMODIUM-FALCIPARUM ARE LOCATED ON A 0.3-MEGABASE REGION OF CHROMOSOME-9 [J].

DAY, KP ;

KARAMALIS, F ;

THOMPSON, J ;

BARNES, DA ;

PETERSON, C ;

BROWN, H ;

BROWN, GV ;

KEMP, DJ .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1993, 90 (17) :8292-8296

[9] Fast determination of haptoglobin phenotype and calculation of hemoglobin binding capacity using high pressure gel permeation chromatography [J].

Delanghe, J ;

Allcock, K ;

Langlois, M ;

Claeys, L ;

De Buyzere, M .

CLINICA CHIMICA ACTA, 2000, 291 (01) :43-51

[10]

Dobryszycka W, 1997, EUR J CLIN CHEM CLIN, V35, P647