Enteropathogenic Escherichia coli:: cellular harassment

被引:17
作者
DeVinney, R [1 ]
Knoechel, DG [1 ]
Finlay, BB [1 ]
机构
[1] Univ British Columbia, Biotechnol Lab, Vancouver, BC V6T 1Z4, Canada
基金
加拿大自然科学与工程研究理事会; 英国医学研究理事会;
关键词
D O I
10.1016/S1369-5274(99)80014-9
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
The mechanisms by which enteropathogenic Escherichia coli (EPEC) mediates diarrhea remain a mystery. Recently a number of interesting and at times surprising results have come from studying EPEC interactions with host cells. Identification and characterization of bacterial factors, including Tir, EspA, EspB and EspD, and host responses have expanded our grasp of the diverse effects of EPEC on host cells.
引用
收藏
页码:83 / 88
页数:6
相关论文
共 47 条
[41]   A pathogenic bacterium triggers epithelial signals to form a functional bacterial receptor that mediates actin pseudopod formation [J].
Rosenshine, I ;
Ruschkowski, S ;
Stein, M ;
Reinscheid, DJ ;
Mills, SD ;
Finlay, BB .
EMBO JOURNAL, 1996, 15 (11) :2613-2624
[42]   Attachment of a noninvasive enteric pathogen, enteropathogenic Escherichia coli, to cultured human intestinal epithelial monolayers induces transmigration of neutrophils [J].
Savkovic, SD ;
Koutsouris, A ;
Hecht, G .
INFECTION AND IMMUNITY, 1996, 64 (11) :4480-4487
[43]   Activation of NF-kappa B in intestinal epithelial cells by enteropathogenic Escherichia coli [J].
Savkovic, SD ;
Koutsouris, A ;
Hecht, G .
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY, 1997, 273 (04) :C1160-C1167
[44]   Enteropathogenic Escherichia coli markedly decreases the resting membrane potential of Caco-2 and HeLa human epithelial cells [J].
Stein, MA ;
Mathers, DA ;
Yan, H ;
Baimbridge, KG ;
Finlay, BB .
INFECTION AND IMMUNITY, 1996, 64 (11) :4820-4825
[45]   EspB and EspD require a specific chaperone for proper secretion from enteropathogenic Escherichia coli [J].
Wainwright, LA ;
Kaper, JB .
MOLECULAR MICROBIOLOGY, 1998, 27 (06) :1247-1260
[46]   Protein translocation into host epithelial cells by infecting enteropathogenic Escherichia coli [J].
Wolff, C ;
Nisan, I ;
Hanski, E ;
Frankel, G ;
Rosenshine, I .
MOLECULAR MICROBIOLOGY, 1998, 28 (01) :143-155
[47]   Enteropathogenic Escherichia coli-induced myosin light chain phosphorylation alters intestinal epithelial permeability [J].
Yuhan, R ;
Koutsouris, A ;
Savkovic, SD ;
Hecht, G .
GASTROENTEROLOGY, 1997, 113 (06) :1873-1882