Role of plasma proteins in pharmacokinetics of micafungin, an antifungal antibiotic, in analbuminemic rats

被引：15

作者：

Abe, Fumie ^{[1
]}

Ueyama, Jun ^{[2
]}

Kawasumi, Noriyo ^{[1
]}

Nadai, Masayuki ^{[3
]}

Hayashi, Tamon ^{[1
]}

Kato, Miki ^{[1
]}

Ohnishi, Masafumi ^{[1
]}

Saito, Hiroko ^{[1
]}

Takeyama, Naoshi ^{[4
]}

Hasegawa, Takaaki ^{[1
]}

机构：

[1] Aichi Med Univ, Sch Med, Dept Pharm & Pharmacokinet, Nagakute, Aichi 4801195, Japan

[2] Nagoya Univ, Sch Hlth Sci, Dept Med Technol, Higashi Ku, Nagoya, Aichi 4618672, Japan

[3] Meijo Univ, Fac Pharmaceut Sci, Tenpaku Ku, Nagoya, Aichi 4688503, Japan

[4] Aichi Med Univ, Sch Med, Dept Crit Care Med, Nagakute, Aichi 4801195, Japan

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2008年 / 52卷 / 09期

关键词：

D O I：

10.1128/AAC.00396-08

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

There were no significant differences in the pharmacokinetics of micafungin and expression of hepatic multidrug resistance-associated protein 2 (ABCC2/Mrp2) between analbuminemic and Sprague-Dawley rats. Micafungin bound strongly to high-density lipoprotein (HDL) and moderately to gamma globulin. These results suggest that HDL and gamma globulin contribute to the pharmacokinetics of micafungin.

引用

页码：3454 / 3456

页数：3

共 21 条

[1]

ABE F, LIFE SCI IN PRESS

[2] Pharmacokinetics of oltipraz in mutant Nagase analbuminemic rats [J].

Bae, SK ;

Kang, HE ;

Kang, MK ;

Kim, JW ;

Kim, T ;

Lee, MG .

JOURNAL OF PHARMACEUTICAL SCIENCES, 2006, 95 (05) :998-1005

[3] Pharmacokinetics of 5-fluorouracil in mutant Nagase analbuminemic rats: Faster metabolism of 5-fluorouracil via CYP1A [J].

Choi, Young H. ;

Bae, Soo K. ;

Kim, Sun O. ;

Lee, Myung G. .

BIOPHARMACEUTICS & DRUG DISPOSITION, 2007, 28 (02) :87-95

[4] Concomitant tacrolimus and micafungin pharmacokinetics in healthy volunteers [J].

Hebert, ME ;

Blough, DK ;

Townsend, RW ;

Allison, M ;

Buell, D ;

Keirns, J ;

Bekersky, I .

JOURNAL OF CLINICAL PHARMACOLOGY, 2005, 45 (09) :1018-1024

[5] Concomitant cyclosporine and micafungin pharmacokinetics in healthy volunteers [J].

Hebert, ME ;

Townsend, RW ;

Austin, S ;

Balan, G ;

Blough, DK ;

Buell, D ;

Keirns, J ;

Bekersky, I .

JOURNAL OF CLINICAL PHARMACOLOGY, 2005, 45 (08) :954-960

[6]

KANEKO H, 2002, JPN J CHEMOTHER S1, V50, P88

[7] Pharmacokinetics of intravenous theophylline in mutant Nagase analbuminemic rats [J].

Kim, EJ ;

Suh, OK ;

Lee, MG .

LIFE SCIENCES, 2003, 72 (11) :1231-1245

[8] Pharmacokinetics and pharmacodynamics of intravenous azosemide in mutant nagase analbuminemic rats [J].

Kim, EJ ;

Lee, AK ;

Kim, SH ;

Kim, SG ;

Lee, MG .

DRUG METABOLISM AND DISPOSITION, 2003, 31 (02) :194-201

[9] Pharmacokinetics and pharmacodynamics of intravenous torasemide in mutant nagase analbuminemic rats [J].

Kim, EJ ;

Lee, MG .

BIOPHARMACEUTICS & DRUG DISPOSITION, 2003, 24 (01) :27-35

[10] Pharmacokinetic behavior of micafungin in rats with carbon tetrachloride-induced acute hepatic failure [J].

Konishi, H ;

Sudo, M ;

Sumi, M ;

Morii, H ;

Minouchi, T ;

Amoto, T ;

Yamaji, A .

BIOLOGICAL & PHARMACEUTICAL BULLETIN, 2005, 28 (03) :556-559

← 1 2 3 →