Pharmacokinetic behavior of micafungin in rats with carbon tetrachloride-induced acute hepatic failure

被引：11

作者：

Konishi, H ^{[1
]}

Sudo, M

Sumi, M

Morii, H

Minouchi, T

Amoto, T

Yamaji, A

机构：

[1] Shiga Univ Med Sci, Dept Hosp Pharm, Otsu, Shiga 5202192, Japan

[2] Setsunan Univ, Fac Pharmaceut Sci, Hirakata, Osaka 5730101, Japan

来源：

BIOLOGICAL & PHARMACEUTICAL BULLETIN | 2005年 / 28卷 / 03期

关键词：

micafungin pharmacokinetics; acute hepatic failure rat; carbon tetrachloride; tissue distribution; elimination clearance;

D O I：

10.1248/bpb.28.556

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

We examined the pharmacokinetic behavior of micafungin, a novel antifungal agent, in rats receiving carbon tetrachloride (CCl4) at a single dose of 2.5 ml/kg. There was no significant change in the total clearance (CLtot) in CCl4-treated rats, while the steady-state volume of distribution (Vd(ss)) was significantly increased by CCl4 treatment. Alteration in the serum unbound fraction of micafungin after CCl4 treatment was unlikely in light of the serum albumin, bilirubin, creatinine, and urea nitrogen. The increased Vd(ss) was attributable to augmentation in the accessibility of micafungin to peripheral tissue without impairment of the intrinsic clearance, because slight enhancement of the tissue distribution of micafungin was confirmed following CCl4 treatment.

引用

页码：556 / 559

页数：4

共 24 条

[1] Oxidative damage to the lipids and proteins of the lungs, testis and kidney of rats during carbon tetrachloride intoxication [J].