Heritability in the genomics era - concepts and misconceptions

被引:1198
作者
Visscher, Peter M. [1 ]
Hill, William G. [2 ]
Wray, Naomi R. [1 ]
机构
[1] Queensland Inst Med Res, Brisbane, Qld 4029, Australia
[2] Univ Edinburgh, Sch Biol Sci, Inst Evolutionary Biol, Edinburgh EH9 3JT, Midlothian, Scotland
基金
澳大利亚研究理事会; 英国医学研究理事会;
关键词
D O I
10.1038/nrg2322
中图分类号
Q3 [遗传学];
学科分类号
071007 ; 090102 ;
摘要
Heritability allows a comparison of the relative importance of genes and environment to the variation of traits within and across populations. The concept of heritability and its definition as an estimable, dimensionless population parameter was introduced by Sewall Wright and Ronald Fisher nearly a century ago. Despite continuous misunderstandings and controversies over its use and application, heritability remains key to the response to selection in evolutionary biology and agriculture, and to the prediction of disease risk in medicine. Recent reports of substantial heritability for gene expression and new estimation methods using marker data highlight the relevance of heritability in the genomics era.
引用
收藏
页码:255 / 266
页数:12
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