Transcriptional enhancer factor 1 (TEF-1/TEAD1) mediates activation of IFITM3 gene by BRG1

被引：9

作者：

Cuddapah, Suresh ^{[1
]}

Cui, Kairong ^{[1
]}

Zhao, Keji ^{[1
]}

机构：

[1] NHLBI, Lab Mol Immunol, NIH, Bethesda, MD 20892 USA

来源：

FEBS LETTERS | 2008年 / 582卷 / 02期

关键词：

TEF-1; BRG1; BAF complex; IFITM3; interferon; TEAD1;

D O I：

10.1016/j.febslet.2007.12.033

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The interferon inducible transmembrane (IFITM) proteins mediate several cellular processes such as homotypic cell adhesion functions of interferons (IFNs) and cellular anti-proliferative activities. We show that the BAF complex-mediated induction of IFITM3 is dependent on binding of the transcriptional enhancer factor I (TEF-1/TEAD1) to the M-CAT like elements of its promoter. TEF-1 knock-down reduced the BAF complex-mediated activation of IFITM3 promoter. In the absence of the BAF complex, TEF-1 is repressive to IFITM3 expression. The regulation of IFITM3 by TEF-1 demonstrates that TEF-1 dependent regulation is more widespread than its previously established role in the expression of muscle specific genes. Published by Elsevier B.V. on behalf of the Federation of European Biochemical Societies.

引用

页码：391 / 397

页数：7

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