Infrared signature of DNA G-quadruplexes in the gas phase

被引：57

作者：

Gabelica, Valerie ^{[1
]}

Rosu, Frederic ^{[1
]}

De Pauw, Edwin ^{[1
]}

Lemaire, Joel ^{[2
]}

Gillet, Jean-Christophe ^{[3
]}

Poully, Jean-Christophe ^{[3
]}

Lecomte, Frederic ^{[3
]}

Gregoire, Gilles ^{[3
]}

Schermann, Jean-Pierre ^{[3
]}

Desfrancois, Charles ^{[3
]}

机构：

[1] Univ Liege, Chem Inst B6c, Mass Spectrometry Lab, B-4000 Liege, Belgium

[2] Univ Paris 11, CNRS, CLIO, Chim Phys Lab, F-91405 Orsay, France

[3] Univ Paris 13, CNRS, Phys Lasers Lab, F-93430 Villetaneuse, France

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2008年 / 130卷 / 06期

关键词：

D O I：

10.1021/ja077321w

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

DNA oligonucleotide ions forming G-quadruplex structures were studied in the gas phase using IRMPD spectroscopy. Data interpretation on these large biomolecule ions was made using carefully chosen control experiments. The major finding is a fingerprint of hydrogen bonding in the gas phase in the guanine C-6=O-6 stretching mode that allows probing of the conservation of G-quartets in the gas phase. The experiments demonstrate the conservation of G-quadruplex hydrogen bonds in the human telomeric sequence d(TTAGGG)(4).

引用

页码：1810 / +

页数：3

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