DNA and its associated processes as targets for cancer therapy

被引：1207

作者：

Hurley, LH

机构：

[1] Univ Arizona, Tucson, AZ 85721 USA

[2] Univ Arizona, Arizona Canc Ctr, Tucson, AZ 85724 USA

来源：

NATURE REVIEWS CANCER | 2002年 / 2卷 / 03期

关键词：

D O I：

10.1038/nrc749

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

DNA is the molecular target for many of the drugs that are used in cancer therapeutics, and is viewed as a non-specific target of cytotoxic agents. Although this is true for traditional chemotherapeutics, other agents that were discovered more recently have shown enhanced efficacy Furthermore, a new generation of agents that target DNA-associated processes are anticipated to be far more specific and effective. How have these agents evolved, and what are their molecular targets?

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页码：188 / 200

页数：13

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