Get ready to GO! A biologist's guide to the Gene Ontology

被引：65

作者：

Lomax, J ^{[1
]}

机构：

[1] European Bioinformat Inst, Cambridge CB10 1SD, England

来源：

BRIEFINGS IN BIOINFORMATICS | 2005年 / 6卷 / 03期

关键词：

Gene Ontology; microarray; gene annotation; model organism database; controlled vocabulary;

D O I：

10.1093/bib/6.3.298

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

The Gene Ontology (GO) project provides a controlled vocabulary to facilitate high-quality functional gene annotation for all species. Genes in biological databases are linked to GO terms, allowing biologists to ask questions about gene function in a manner independent of species. This tutorial provides an introduction for biologists to the GO resources and covers three of the most common methods of querying GO: by individual gene, by gene function and by using a list of genes. [For the sake of brevity, the term 'gene' is used throughout this paper to refer to genes and their products (proteins and RNAs). GO annotations are always based on the characteristics of gene products, even though it may be the gene that is cited in the annotation].

引用

页码：298 / 304

页数：7

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