The microcosmos of cancer

被引：1105

作者：

Lujambio, Amaia ^{[1
]}

Lowe, Scott W. ^{[1
,2
]}

机构：

[1] MSKCC, Canc Biol & Genet Program, New York, NY 10065 USA

[2] MSKCC, Howard Hughes Med Inst, New York, NY 10065 USA

来源：

NATURE | 2012年 / 482卷 / 7385期

关键词：

EPITHELIAL-MESENCHYMAL TRANSITION; DOWN-REGULATION; POSTTRANSCRIPTIONAL REGULATION; MICRORNA EXPRESSION; ACTIVATED MICRORNA; TUMOR SUPPRESSORS; RNA INTERFERENCE; P53; NETWORK; LUNG-CANCER; MYC;

D O I：

10.1038/nature10888

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

070301 [无机化学]; 070403 [天体物理学]; 070507 [自然资源与国土空间规划学]; 090105 [作物生产系统与生态工程];

摘要：

The discovery of microRNAs (miRNAs) almost two decades ago established a new paradigm of gene regulation. During the past ten years these tiny non-coding RNAs have been linked to virtually all known physiological and pathological processes, including cancer. In the same way as certain key protein-coding genes, miRNAs can be deregulated in cancer, in which they can function as a group to mark differentiation states or individually as bona fide oncogenes or tumour suppressors. Importantly, miRNA biology can be harnessed experimentally to investigate cancer phenotypes or used therapeutically as a target for drugs or as the drug itself.

引用

页码：347 / 355

页数：9

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