Evaluation of polymeric nanoparticles composed of cholic acid and methoxy poly(ethylene glycol)

被引：26

作者：

Kim, IS ^{[1
]}

Kim, SH ^{[1
]}

机构：

[1] Chosun Univ, Coll Pharm, Dept Biol Chem, Kwangju 501759, South Korea

来源：

INTERNATIONAL JOURNAL OF PHARMACEUTICS | 2001年 / 226卷 / 1-2期

关键词：

amphiphilic polymer; polymeric conjugate; cholic acid; poly(ethylene glycol); nanoparticle;

D O I：

10.1016/S0378-5173(01)00756-6

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Amphiphilic polymeric conjugate based on cholic acid (CA) as the hydrophobic component and methoxy poly(ethylene glycol) (MPEG) as the hydrophilic component was synthesized using a 1,1'-carbonyidiimidazole (CDI) mediated conjugation. Fluorescence spectroscopy measurements suggested that CA and MPEG (abbreviated as CE) conjugate was associated in water to form polymeric core-shell type nanoparticles with a critical association concentration (CAC) value of 0.063 g l(-1). From the transmission electron microscope (TEM) observation, CE nanoparticles were almost spherical with a size range of approximately 10-30 nm in the dried state, which was in agreement with the result from particle size measurement using photon correlation spectroscopy (PCS). Clonazepam (CNZ) was physically loaded into the CE nanoparticles with a 16.2 wt.% loading. CNZ release was pseudo zero.-order in kinetic terms for up to 3 days. (C) 2001 Elsevier Science B.V. All rights reserved.

引用

页码：23 / 29

页数：7