DNA methylation: The nuts and bolts of repression

被引：465

作者：

Miranda, Tina Branscombe ^{[1
]}

Jones, Peter A. ^{[1
]}

机构：

[1] Univ So Calif, Kenneth Norris Jr Comprehens Canc Ctr, Keck Sch Med, Dept Urol Biochem & Mol Biol, Los Angeles, CA 90033 USA

来源：

JOURNAL OF CELLULAR PHYSIOLOGY | 2007年 / 213卷 / 02期

关键词：

D O I：

10.1002/jcp.21224

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

DNA methylation is an epigenetic modification which plays an important role in chromatin organization and gene expression. DNA methylation can silence genes and repetitive elements through a process which leads to the alteration of chromatin structure. The mechanisms which target DNA methylation to specific sites in the genome are not fully understood. In this review, we will discuss the mechanisms which lead to the long-term silencing of genes and will survey the progression that has been made in determining the targeted mechanisms for de novo DNA methylation.

引用

页码：384 / 390

页数：7

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