A novel and general route to diverse A-ring aromatic trichothecanes via cyclobutanes

被引：27

作者：

Nemoto, H ^{[1
]}

Miyata, J ^{[1
]}

Fukumoto, K ^{[1
]}

机构：

[1] TOHOKU UNIV,INST PHARMACEUT,AOBA KU,SENDAI,MIYAGI 98077,JAPAN

来源：

TETRAHEDRON | 1996年 / 52卷 / 31期

关键词：

D O I：

10.1016/0040-4020(96)00549-2

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A novel and generally applicable approach to A-ring aromatic trichothecane 2 was achieved by the regiocontrolled cyclization of 25, 26, 29, and 30 as a key step, followed by stereoselective construction of the epoxide ring. This manuscript also described the regiocontrolled ring expansion of the olefinic cyclobutanols 19-22 to give the enones 23 and 24 which were the important intermediates in this approach. Copyright (C) 1996 Elsevier Science Ltd

引用

页码：10363 / 10374

页数：12

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