Synthesis and properties of C-azalyxonucleosides

被引：31

作者：

Momotake, A

Mito, J

Yamaguchi, K

Togo, H

Yokoyama, M

机构：

[1] Chiba Univ, Grad Sch Sci & Technol, Dept Chem, Inage Ku, Chiba 2638522, Japan

[2] Chiba Univ, Ctr Chem Anal, Inage Ku, Chiba 2638522, Japan

来源：

JOURNAL OF ORGANIC CHEMISTRY | 1998年 / 63卷 / 21期

关键词：

D O I：

10.1021/jo980492m

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

1-beta-(4-Imidazoyl)- and 1-beta-(5-uracilyl)-1,4-dideoxy-1,4-imino-L-lyxitols were synthesized stereoselectively via a sequential procedure by the addition of the corresponding metal salts of heterocycles, Swern oxidation, reductive aminocyclization, and deprotection. Their structures were determined based on X-ray crystallography. From the NMR measurements of their N-acyl derivatives, two rotational isomers were observed. Their bioassay is also described.

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页码：7207 / 7212

页数：6

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