Noninferiority of antibody response to human papillomavirus type 16 in subjects vaccinated with monovalent and quadrivalent L1 virus-like particle vaccines

被引：34

作者：

Garland, Suzanne M.

Steben, Marc

Hernandez-Avila, Mauricio

Koutsky, Laura A.

Wheeler, Cosette M.

Perez, Gonzalo

Harper, Diane M.

Leodolter, Sepp

Tang, Grace W. K.

Ferris, Daron G.

Esser, Mark T.

Vuocolo, Scott C.

Nelson, Micki

Railkar, Radha

Sattler, Carlos

Barr, Eliav

机构：

[1] Inst Natl Sante Publ Quebec, Direct Risques Biol Environm & Occupat, Montreal, PQ H2P 1E2, Canada

[2] Royal Hosp Women, Dept Microbiol & Infect Dis, Carlton, Vic, Australia

[3] Univ Melbourne, Dept Obstet & Gynaecol, Melbourne, Vic, Australia

[4] Natl Inst Publ Hlth, Cuernavaca, Morelos, Mexico

[5] Univ Washington, Dept Epidemiol, Seattle, WA 98195 USA

[6] Univ New Mexico, Dept Mol Genet & Microbiol, Albuquerque, NM 87131 USA

[7] Univ New Mexico, Dept Obstet & Gynecol, Albuquerque, NM 87131 USA

[8] Natl Res Ctr, Grp Saludcoop, Bogota, Colombia

[9] Dartmouth Med Sch, Norris Cotton Canc Ctr, Dept Obstet & Gynecol, Hanover, NH USA

[10] Dartmouth Med Sch, Norris Cotton Canc Ctr, Dept Community & Family Med, Hanover, NH USA

[11] Med Univ Vienna, Womens Hlth Clin, Dept Gynecol & Obstet, Vienna, Austria

[12] Univ Hong Kong, Dept Obstet & Gynecol, Hong Kong, Peoples R China

[13] Med Coll Georgia, Dept Family Med, Augusta, GA 30912 USA

[14] Med Coll Georgia, Dept Obstet & Gynecol, Augusta, GA 30912 USA

[15] Merck Res Labs, West Point, PA USA

来源：

CLINICAL AND VACCINE IMMUNOLOGY | 2007年 / 14卷 / 06期

关键词：

D O I：

10.1128/CVI.00478-06

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The incorporation of multiple antigens into a single human papillomavirus (HPV) vaccine may induce immune interference. To evaluate whether interference occurs when HPV type 16 (HPV16) virus-like particles are combined in a multivalent vaccine, we conducted a study to evaluate anti-HPV16 responses among subjects receiving three-dose regimens of either a monovalent HPV16 vaccine or a quadrivalent HPV (types 6, 11, 16, and 18) vaccine.

引用

页码：792 / 795

页数：4

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