Chemistry and biology of DNA repair

被引：313

作者：

Schärer, OD ^{[1
]}

机构：

[1] Univ Zurich, Inst Mol Canc Res, CH-8008 Zurich, Switzerland

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2003年 / 42卷 / 26期

关键词：

cancer; DNA damage; DNA repair enzyme catalysis; molecular recognition;

D O I：

10.1002/anie.200200523

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Numerous agents of endogenous and exogenous origin damage DNA in our genome. There are several DNA-repair pathways that recognize lesions in DNA and remove them through a number of diverse reaction sequences. Defects in DNA-repair proteins are associated with several human hereditary syndromes, which show a marked predisposition to cancer. Although DNA repair is essential for a healthy cell, DNA-repair enzymes counteract the efficiency of a number of important antitumor agents that exert their cytotoxic effects by damaging DNA. DNA-repair enzymes are therefore also targets for drug design. DNA-repair processes differ greatly in their nature and complexity. Whereas some pathways only require a single enzyme to restore the original DNA sequence, others operate through the coordinated action of 30 or more proteins. Our understanding of the genetic, biochemical, and structural basis of DNA repair and related processes has increased dramatically over the past decade. This review summarizes the latest developments in this field.

引用

页码：2946 / 2974

页数：29

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