Antioxidant capacity of G-6-PD-deficient erythrocytes

Glucose-6-phosphate dehydrogenase (C-B-PD) deficiency is the most common human enzymopathy. In this research, we studied two groups consisting of 30 male subjects who are G-6-PD deficient and 30 normal male subjects marched with the G-6-PD-deficient patients fur age. All 30 assays were performed under normal conditions free of any oxidative attach that may result in haemolytic crisis in G-6-PD-deficient subjects. The erythrocyte glucose-6-phosphate dehydrogenase, superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GSH-Px), glutathione-S-transfer ase (GST) activities, reduced glutathione (GSH) levels and erythrocyte and plasma thiobarbituric acid-reactive substances (TBARS) levels were measured. All parameters in each group did not differ significantly except for G-6-PD levels. These data show that G-6-PD-deficient subjects can survive in normal conditions unless they are exposed to any oxidative stress. (C) 2001 Elsevier Science B.V. All rights reserved.