Role of protein kinase B in insulin-regulated glucose uptake

被引：103

作者：

Welsh, GL ^{[1
]}

Hers, I ^{[1
]}

Berwick, DC ^{[1
]}

Dell, G ^{[1
]}

Wherlock, M ^{[1
]}

Birkin, R ^{[1
]}

Leney, S ^{[1
]}

Tavaré, JM ^{[1
]}

机构：

[1] Univ Bristol, Dept Biochem, Sch Med Sci, Bristol BS8 1TD, Avon, England

来源：

BIOCHEMICAL SOCIETY TRANSACTIONS | 2005年 / 33卷

关键词：

AS; 160; glucose uptake; GLUT4; insulin; PIKfyve; protein kinase B;

D O I：

10.1042/BST0330346

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The activation of protein kinase B (or Akt) plays a central role in the stimulation of glucose uptake by insulin. Currently, however, numerous questions remain unanswered regarding the role of this kinase in bringing about this effect. For example, we do not know precisely where in the GLUT4 trafficking pathway this kinase acts. Nor do we know which protein substrates are responsible for mediating the effects of protein kinase 13, although two recently identified proteins (AS160 and PIKfyve) may play a role. This paper addresses these important questions by reviewing recent progress in the field.

引用

页码：346 / 349

页数：4

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