Deep Penetration of a PDT Drug into Tumors by Noncovalent Drug-Gold Nanoparticle Conjugates

被引:251
作者
Cheng, Yu [3 ]
Meyers, Joseph D. [1 ,2 ,3 ]
Broome, Ann-Marie [1 ,2 ]
Kenney, Malcolm E. [3 ]
Basilion, James P. [1 ,2 ]
Burda, Clemens [3 ]
机构
[1] Case Western Reserve Univ, Dept Biomed Engn, NFCR Ctr Mol Imaging, Cleveland, OH 44106 USA
[2] Case Western Reserve Univ, Dept Radiol, NFCR Ctr Mol Imaging, Cleveland, OH 44106 USA
[3] Case Western Reserve Univ, Dept Chem, NFCR Ctr Mol Imaging, Cleveland, OH 44106 USA
关键词
LOW-DENSITY-LIPOPROTEIN; 4 PHOTODYNAMIC THERAPY; COLLOIDAL GOLD; ENHANCED PERMEABILITY; ANTICANCER DRUGS; DELIVERY SYSTEMS; SINGLET OXYGEN; CANCER-THERAPY; QUANTUM DOTS; PHOTOSENSITIZERS;
D O I
10.1021/ja108846h
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Efficient drug delivery to tumors is of ever-increasing importance. Single-visit diagnosis and treatment sessions are the goal of future theranostics. In this work, a noncovalent PDT cancer drug-gold nanoparticle (Au NP) conjugate system performed a rapid drug release and deep penetration of the drug into tumors within hours. The drug delivery mechanism of the PDT drug through Au NPs into tumors by passive accumulation was investigated via fluorescence imaging, elemental analysis, and histological staining. The pharmacokinetics of the conjugates over a 7-day test period showed rapid drug excretion, as monitored via the fluorescence of the drug in urine. Moreover, the biodistribution of Au NPs in this study period indicated clearance of the NPs from the mice. This study suggests that noncovalent delivery via Au NPs provides an attractive approach for cancer drugs to penetrate Jeep into the center of tumors.
引用
收藏
页码:2583 / 2591
页数:9
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