Paecilosetin, a new bioactive fungal metabolite from a New Zealand isolate of Paecilomyces farinosus

被引：59

作者：

Lang, G

Blunt, JW

Cummings, NJ

Cole, ALJ

Munro, MHG

机构：

[1] Univ Canterbury, Dept Chem, Christchurch, New Zealand

[2] Univ Canterbury, Sch Biol Sci, Christchurch, New Zealand

来源：

JOURNAL OF NATURAL PRODUCTS | 2005年 / 68卷 / 05期

关键词：

D O I：

10.1021/np0500979

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

A new tetramic acid derivative, paecilosetin (1), along with a recently characterized N-hydroxypyridone, farinosone B (2), was isolated from the fungus Paecilomyces farinosus. Each compound showed activity against the P388 cell line with IC50 values of 3.1 and 1.1 mu g/mL, respectively. Paecilosetin was also active against the microorganisms Bacillus subtilis, Trichophyton mentagrophytes, and Cladosporium resinae.

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页码：810 / 811

页数：2

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