Protein kinase D in the cardiovascular system - Emerging roles in health and disease

被引：96

作者：

Avkiran, Metin ^{[1
]}

Rowland, Alexandra J. ^{[1
]}

Cuello, Friederike ^{[1
]}

Haworth, Robert S. ^{[1
]}

机构：

[1] Kings Coll London, Div Cardiovasc, Rayne Inst, St Thomas Hosp, London SE1 7EH, England

来源：

CIRCULATION RESEARCH | 2008年 / 102卷 / 02期

基金：

英国医学研究理事会;

关键词：

protein kinase D; signal transduction; contraction; hypertrophy; remodeling; ischemia;

D O I：

10.1161/CIRCRESAHA.107.168211

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The protein kinase D (PKD) family is a recent addition to the calcium/calmodulin-dependent protein kinase group of serine/threonine kinases, within the protein kinase complement of the mammalian genome. Relative to their alphabetically superior cousins in the AGC group of kinases, namely the various isoforms of protein kinase A, protein kinase B/Akt, and protein kinase C, PKD family members have to date received limited attention from cardiovascular investigators. Nevertheless, increasing evidence now points toward important roles for PKD-mediated signaling pathways in the cardiovascular system, particularly in the regulation of myocardial contraction, hypertrophy and remodeling. This review provides a primer on PKD signaling, using information gained from studies in multiple cell types, and discusses recent data that suggest novel functions for PKD-mediated pathways in the heart and the circulation.

引用

页码：157 / 163

页数：7

共 85 条

[1] Rapid activation of the novel serine/threonine protein kinase, protein kinase D by phorbol esters, angiotensin II and PDGF-BB in vascular smooth muscle cells [J].

Abedi, H ;

Rozengurt, E ;

Zachary, I .

FEBS LETTERS, 1998, 427 (02) :209-212

[2] Activation of hematopoietic progenitor kinase 1 involves relocation, autophosphorylation, and transphosphorylation by protein kinase D1 [J].

Arnold, R ;

Patzak, IM ;

Neuhaus, B ;

Vancauwenbergh, S ;

Veillette, A ;

Van Lint, J ;

Kiefer, F .

MOLECULAR AND CELLULAR BIOLOGY, 2005, 25 (06) :2364-2383

[3] Control of cardiac growth by histone acetylation/deacetylation [J].

Backs, J ;

Olson, EN .

CIRCULATION RESEARCH, 2006, 98 (01) :15-24

[4] The selectivity of protein kinase inhibitors: a further update [J].

Bain, Jenny ;

Plater, Lorna ;

Elliott, Matt ;

Shpiro, Natalia ;

Hastie, C. James ;

Mclauchlan, Hilary ;

Klevernic, Iva ;

Arthur, J. Simon C. ;

Alessi, Dario R. ;

Cohen, Philip .

BIOCHEMICAL JOURNAL, 2007, 408 :297-315

[5] Role of diacylglycerol in PKD recruitment to the TGN and protein transport to the plasma membrane [J].

Baron, CL ;

Malhotra, V .

SCIENCE, 2002, 295 (5553) :325-328

[6] Preconditioning: a paradigm shift in the biology of myocardial ischemia [J].

Bolli, Roberto .

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, 2007, 292 (01) :H19-H27

[7]

Bossuyt J, 2006, CIRCULATION, V114, P54

[8] Phorbol ester, but not ischemic preconditioning, activates protein kinase D in the rat heart [J].

Brooks, G ;

Goss, MW ;

Rozengurt, E ;

Galinanes, M .

JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, 1997, 29 (08) :2273-2283

[9] Protein kinase D selectively targets cardiac troponin I and regulates myofilament Ca2+ sensitivity in ventricular myocytes [J].

Cuello, Friederike ;

Bardswell, Sonya C. ;

Haworth, Robert S. ;

Yin, Xiaoke ;

Lutz, Susanne ;

Wieland, Thomas ;

Mayr, Manuel ;

Kentish, Jonathan C. ;

Avkiran, Metin .

CIRCULATION RESEARCH, 2007, 100 (06) :864-873

[10] Phosphorylation of histone deacetylase 7 by protein kinase D mediates T cell receptor-induced Nur77 expression and apoptosis [J].

Dequiedt, F ;

Van Lint, J ;

Lecomte, E ;

Van Duppen, V ;

Seufferlein, T ;

Vandenheede, JR ;

Wattiez, R ;

Kettmann, R .

JOURNAL OF EXPERIMENTAL MEDICINE, 2005, 201 (05) :793-804

← 1 2 3 4 5 6 7 8 9 →