Controlled Release of Bis(phosphonate) Pharmaceuticals from Cationic Biodegradable Polymeric Matrices

被引：78

作者：

Demadis, Konstantinos D. ^{[1
]}

Paspalaki, Maria ^{[1
]}

Theodorou, Joanna ^{[1
]}

机构：

[1] Univ Crete, Dept Chem, Crystal Engn Growth & Design Lab, GR-71003 Iraklion, Crete, Greece

来源：

INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH | 2011年 / 50卷 / 09期

关键词：

IN-VIVO; CALCIFICATION; POLYETHYLENIMINE; HYBRID; WATERS;

D O I：

10.1021/ie102546g

中图分类号：

TQ [化学工业];

学科分类号：

0817 ;

摘要：

Herein, the controlled release of etidronic acid (hydroxyethylidene-bis(phosphonic) acid), an important drug for osteoporotic conditions, immobilized onto cationic polymeric matrices, such as polyethyleneimine (PEI) or cationic inulin (CATIN) is reported. Several CATIN- and PEI-etidronate composites have been synthesized at various pH regions and characterized. Tablets with starch as the excipient containing the active ingredient (polymer-etidronate composite) were prepared, and the controlled release of etidronate was studied at aqueous solutions of pH 3 (to mimick the pH of the stomach) for 8 h. All studied composites showed a delayed etidronate release in the first 4 h, compared to the "control" (a tablet containing only starch and etidronic acid, without the polymer).

引用

页码：5873 / 5876

页数：4

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