Function and assembly of the Leishmania surface coat

被引：95

作者：

Ilgoutz, SC ^{[1
]}

McConville, MJ ^{[1
]}

机构：

[1] Univ Melbourne, Dept Biochem & Mol Biol, Parkville, Vic 3010, Australia

来源：

INTERNATIONAL JOURNAL FOR PARASITOLOGY | 2001年 / 31卷 / 09期

关键词：

glycosylphosphatidylinositol; glycolipid; glycocalyx; gene knockout; biosynthesis; Leishmania;

D O I：

10.1016/S0020-7519(01)00197-7

中图分类号：

R38 [医学寄生虫学]; Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ; 100103 ;

摘要：

Like many trypanosomatids, the cell surface coat of Leishmania spp. is responsible for mediating various host-parasite interactions as well as acting as a dense physical barrier. This confers protection to the parasites irt the hostile environments of the sandfly midgut and the macrophage phagolysosome. The major components of the surface coat are tethered to the cell surface via glycosylphosphatidylinositol glycolipids, and the composition of this surface coat is exquisitely regulated during the course of the parasite life-cycle. In this paper, we review what is known about the composition, biosynthesis and function of these glycosylphosphatidylinositol-containing molecules found within the parasite surface coat. (C) 2001 Australian Society for Parasitology Inc. Published by Elsevier Science Ltd. All rights: reserved.

引用

页码：899 / 908

页数：10

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