Magnetic functionalised carbon nanotubes as drug vehicles for cancer lymph node metastasis treatment

被引：205

作者：

Yang, Feng ^{[1
,2
]}

Jin, Chen ^{[1
,2
]}

Yang, Dong ^{[3
]}

Jiang, Yongjian ^{[1
,2
]}

Li, Ji ^{[1
,2
]}

Di, Yang ^{[1
,2
]}

Hu, Jianhua ^{[3
]}

Wang, Changchun ^{[3
]}

Ni, Quanxing ^{[2
,4
]}

Fu, Deliang ^{[1
,2
]}

机构：

[1] Fudan Univ, Pancreat Dis Inst, Dept Pancreat Surg, Huashan Hosp,Shanghai Med Coll, Shanghai 200040, Peoples R China

[2] Fudan Univ, Shanghai Med Coll, Dept Surg, Shanghai 200032, Peoples R China

[3] Fudan Univ, Dept Macromol Sci, Key Lab Mol Engn Polymers Minist Educ, Adv Mat Lab, Shanghai 200433, Peoples R China

[4] Fudan Univ, Pancreat Dis Inst, Dept Pancreat & Hepatobiliary Surg, Canc Hosp,Shanghai Med Coll, Shanghai 200032, Peoples R China

来源：

EUROPEAN JOURNAL OF CANCER | 2011年 / 47卷 / 12期

基金：

美国国家科学基金会;

关键词：

Carbon nanotubes; Cancer; Lymph node metastasis; Gemcitabine; Magnetic targeted; IN-VIVO; PANCREATIC-CANCER; CELLULAR UPTAKE; DELIVERY; AGENTS; THERAPY; CELLS; IMMUNOHISTOCHEMISTRY; NANOMATERIALS; CYTOTOXICITY;

D O I：

10.1016/j.ejca.2011.03.018

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Strategies using carbon-based nanomaterials as carriers for delivering chemotherapeutic drugs to cancers have been described well. Here a novel magnetic lymphatic-targeting drug-delivery system, based on functionalised carbon nanotubes (fCNTs), is presented with the aim of improving the outcome of cancer with lymph node involvement. The potential therapeutic effect of gemcitabine (GEM) loading magnetic multiwalled carbon nanotubes (mMWNTs) was compared with that of GEM loading magnetic-activated carbon particles (mACs) in vitro and in vivo. mMWNTs-GEM and mACs-GEM both had high anti-tumour activity in vitro similar to free drug. Subcutaneous administration of GEM loading magnetic nanoparticles resulted in successful regression and inhibition of lymph node metastasis under the magnetic field, with mMWNTs-GEM superior to mACs-GEM, and more effectively in the high-dose versus low-dose groups. The successful application of Ultra-lymphatic delivery of chemotherapeutics using mMWNTs highlights the clinical potential of fCNTs for future cancer metastasis treatment with high efficacy and minimum side-effects. (C) 2011 Elsevier Ltd. All rights reserved.

引用

页码：1873 / 1882

页数：10

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