Optogenetic approaches to restoring visual function in retinitis pigmentosa

被引：74

作者：

Busskamp, Volker ^{[1
]}

Roska, Botond ^{[1
]}

机构：

[1] Friedrich Miescher Inst Biomed Res, Neural Circuit Labs, Basel, Switzerland

来源：

CURRENT OPINION IN NEUROBIOLOGY | 2011年 / 21卷 / 06期

关键词：

ADENOASSOCIATED VIRAL VECTORS; ECTOPIC EXPRESSION; GENE DELIVERY; CHANNELRHODOPSIN-2; RESPONSES; CELLS; DEGENERATION; MICE; RESTORATION; DEATH;

D O I：

10.1016/j.conb.2011.06.001

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Retinitis pigmentosa is a hereditary eye disease that affects photoreceptors and leads to blindness. The discovery of a microbial light-gated channel and the subsequent development of similar 'optogenetic' sensors have opened the door to creating artificial photoreceptors in the remaining retinal circuits of retinitis pigmentosa retinas via gene therapy. Here we review recent studies in animal models of retinitis pigmentosa that have combined knowledge of retinal cell types, circuits and computations with the ability to equip cell types with optogenetic sensors in order to restore visual activity. We also discuss the translational potential of this therapy.

引用

页码：942 / 946

页数：5

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