Rapid, membrane-initiated actions of 1,25 dihydroxyvitamin D: What are they and what do they mean?

被引：70

作者：

Fleet, JC ^{[1
]}

机构：

[1] Purdue Univ, Dept Food & Nutr, W Lafayette, IN 47907 USA

[2] Purdue Univ, Interdept Nutr Program, W Lafayette, IN 47907 USA

来源：

JOURNAL OF NUTRITION | 2004年 / 134卷 / 12期

关键词：

kinase; ion flux; vitamin D;

D O I：

10.1093/jn/134.12.3215

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

Vitamin D is a conditionally required nutrient traditionally thought to influence physiology as the metabolite 1,25-dihydroxyvitamin D [1,25(OH)(2) D] by binding to the vitamin D receptor (VDR) and stimulating the transcription of genes through direct VDR-DNA interactions. However, over the past 15 y research has demonstrated that 1,25(OH)(2) D, as well as other steroid hormones, can rapidly stimulate ion fluxes and activate protein kinases by transcription-independent mechanisms. This review summarizes recent research on the rapid actions of 1,25(OH)(2) D and identifies questions that remain to be answered in this area.

引用

页码：3215 / 3218

页数：4