Cytoskyrins A and B, new BIA active bisanthraquinones isolated from an endophytic fungus

被引：43

作者：

Brady, SF

Singh, MP

Janso, JE

Clardy, J ^{[1
]}

机构：

[1] Cornell Univ, Dept Chem & Biol Chem, Ithaca, NY 14853 USA

[2] Wyeth Ayerst Res, Nat Prod Microbiol, Pearl River, NY 10956 USA

来源：

ORGANIC LETTERS | 2000年 / 2卷 / 25期

关键词：

D O I：

10.1021/ol006681k

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The biochemical induction assay (BIA) is a rapid (colorimetric) bacterial assay used to identify compounds that damage DNA or inhibit DNA synthesis end thereby identify potential natural product anticancer agents. Bisanthraquinones based on a 1,3,6,8-tetrahydroxyanthraquinone-type carbon skeleton were isolated from an endophytic fungus and characterized by NMR and X-ray crystallography. Cytoskyrin A (1) is highly active in the biochemical induction assay, while the closely related cytoskyrin B (2) has no detectable activity in this assay.

引用

页码：4047 / 4049

页数：3

共 18 条

[1]

BOUCHET JC, 1977, ANN NUTR ALIMENT, V31, P811

[2] The cytosporones, new octaketide antibiotics isolated from an endophytic fungus [J].