Thicker than blood:: Conserved mechanisms in Drosophila and vertebrate hematopoiesis

被引:325
作者
Evans, CJ
Hartenstein, V
Banerjee, U [1 ]
机构
[1] Univ Calif Los Angeles, Dept Mol Cell & Dev Biol, Los Angeles, CA 90095 USA
[2] Univ Calif Los Angeles, Dept Biol Chem, Los Angeles, CA 90095 USA
[3] Univ Calif Los Angeles, Mol Biol Inst, Los Angeles, CA 90095 USA
关键词
D O I
10.1016/S1534-5807(03)00335-6
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Blood development in Drosophila melanogaster shares several interesting features with hematopoiesis in vertebrates, including spatiotemporal regulation as well as the use of similar transcriptional regulators and signaling pathways. In this review, we describe what is known about hematopoietic development in Drosophila and the various cell types generated and their functions. Additionally, the molecular genetic mechanisms of hernatopoietic cell fate determination and commitment within Drosophila blood cell lineages are discussed and compared to vertebrate mechanisms.
引用
收藏
页码:673 / 690
页数:18
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