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Notch signaling in hematopoiesis and early lymphocyte development

被引：74
作者：
Allman, D
Aster, JC
Pear, WS
机构：
[1] Univ Penn, Med Ctr, Dept Pathol & Lab Med, Philadelphia, PA 19104 USA
[2] Univ Penn, Med Ctr, Inst Med & Engn, Philadelphia, PA 19104 USA
[3] Univ Penn, Med Ctr, Abramson Family Canc Res Inst, Philadelphia, PA 19104 USA
[4] Harvard Univ, Sch Med, Brigham & Womens Hosp, Dept Pathol, Boston, MA 02115 USA
来源：
IMMUNOLOGICAL REVIEWS | 2002年 / 187卷
关键词：
D O I：
10.1034/j.1600-065X.2002.18707.x
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Notch signals regulate multiple cell fate decisions during metazoan development. During hematopoiesis, Notch affects both hematopoietic stem cells and committed progenitors. In hematopoietic stem cells, Notch signaling has the propensity to expand the stem cells, promote their self-renewal, and influence their survival. In committed progenitors, Notch signaling plays a key role in determining lymphoid cell fates. This review focuses on recent developments to understand the role of Notch signaling in early events in hematopoiesis.
引用
收藏
页码：75 / 86
页数：12
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