Synthesis of latanoprost diastereoisomers

被引：12

作者：

Obadalová, R ^{[1
]}

Pilarcík, T ^{[1
]}

Slavíková, MF ^{[1
]}

Hájícek, J ^{[1
]}

机构：

[1] ZENTIVA VUFB, R&D Synth Grp 2, API Div, CZ-10237 Prague, Czech Republic

来源：

CHIRALITY | 2005年 / 17卷

关键词：

prostaglandins; glaucoma; Corey's alcohol; chiral cyclopentenone; higher-order cuprate; diastereoselective Michael addition;

D O I：

10.1002/chir.20116

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A new synthesis of latanoprost diastereoisomers is described which utilizes a highly stereoselective Michael addition of higher-order cuprate to a chiral cyclopentenone derived from G-lactone in the crucial skeleton-forming step. Chirality 17:S109-S113, 2005. (c) 2005 Wiley-Liss, Inc.

引用

页码：S109 / S113

页数：5