One-step, room temperature, colorimetric detection of mercury (Hg2+) using DNA/nanoparticle conjugates

被引：633

作者：

Xue, Xuejia ^{[1
]}

Wang, Feng ^{[1
]}

Liu, Xiaogang ^{[1
]}

机构：

[1] Natl Univ Singapore, Dept Chem, Singapore 117543, Singapore

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2008年 / 130卷 / 11期

关键词：

D O I：

10.1021/ja076716c

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Introduction of Hg2+ into an aqueous solution containing oligonucleotide-tethered gold nanoparticle probes and a linker oligonucleolide with a number of thymine-thymine (T-T) mismatches results in the formation of particle aggregates at room temperature with a concomitant colorimetric response. The high selectivity of this detection system is attributed to Hg2+-mediated formation of T-Hg2+-T base pairs as evidenced by an increase in a sharp melting temperature.

引用

页码：3244 / +

页数：3

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