miRNA-146a in rheumatoid arthritis: a new therapeutic strategy

被引：39

作者：

Pauley, Kaleb M. ^{[1
]}

Cha, Seunghee ^{[1
]}

机构：

[1] Univ Florida, Coll Dent, Dept Oral & Maxillofacial Diagnost Sci, Gainesville, FL 32610 USA

来源：

IMMUNOTHERAPY | 2011年 / 3卷 / 07期

关键词：

autoimmune disease; miRNA-146a; miRNA therapy; osteoclastogenesis; rheumatoid arthritis; MICRORNA-146A EXPRESSION; LUPUS; MIR-146A; CELLS;

D O I：

10.2217/IMT.11.70

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

071005 [微生物学]; 100108 [医学免疫学];

摘要：

Evaluation of: Nakasa T, Shibuya H, Nagata Y, Niimoto T, Ochi M: The inhibitory effect of microRNA-146a expression on bone destruction in collagen-induced arthritis. Arthritis Rheum. 63(6), 1582-1590 (2011). miRNA-146a (miR-146a) has been shown to play an important role in the negative regulation of inflammatory innate immune responses, and is differentially expressed in a number of human diseases including rheumatoid arthritis. However, evidence for the potential therapeutic use of miR-146a in human disease has been lacking. The current paper demonstrates the potential therapeutic application of miR-146a for rheumatoid arthritis by demonstrating the inhibitory effect of miR-146a on osteoclastogenesis in vitro. Moreover, using a collagen-induced arthritis mouse model, they were able to demonstrate that intravenous administration of double-stranded miR-146a resulted in the suppression of cartilage and bone destruction, despite relatively unaffected immune cell infiltration of the synovium and inflammatory cytokine expression.

引用

页码：829 / 831

页数：3

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