MicroRNA-146a and Human Disease

被引：254

作者：

Li, L. ^{[1
]}

Chen, X. -P. ^{[1
]}

Li, Y. -J. ^{[1
]}

机构：

[1] Cent S Univ, Dept Pharmacol, Sch Pharmaceut Sci, Changsha 410078, Hunan, Peoples R China

来源：

SCANDINAVIAN JOURNAL OF IMMUNOLOGY | 2010年 / 71卷 / 04期

基金：

美国国家科学基金会;

关键词：

EPSTEIN-BARR-VIRUS; PAPILLARY THYROID-CARCINOMA; RHEUMATOID-ARTHRITIS; FUNCTIONAL POLYMORPHISM; SIGNALING PROTEINS; IMMUNE-RESPONSE; SYNOVIAL TISSUE; MIR-146A GENE; RIG-I; EXPRESSION;

D O I：

10.1111/j.1365-3083.2010.02383.x

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

071005 [微生物学]; 100108 [医学免疫学];

摘要：

MicroRNAs (MiRNAs) belong to a class of small non-coding regulatory RNAs that act through repression of protein expression at post-transcriptional level and emerge to play important roles in many physiological and pathophysiological processes. MiR-146a is a miRNA supposed to regulate innate immune, inflammatory response and antiviral pathway negatively. In this review, we focus on the recent progress in functional role of miR-146a in innate immune, inflammatory response, virus infection and human diseases. Together, these findings indicate that manipulation of miR-146a expression may represent a potential new therapy for several human diseases. Potential use of miR-146a as a biomarker for disease diagnosis, prevention and treatment is also discussed.

引用

页码：227 / 231

页数：5

共 53 条

[1]

The functions of animal microRNAs [J].

Ambros, V .

NATURE, 2004, 431 (7006) :350-355

[2]

MicroRNAs in Organogenesis and Disease [J].

Asli, Naisana S. ;

Pitulescu, Mara E. ;

Kessel, Michael .

CURRENT MOLECULAR MEDICINE, 2008, 8 (08) :698-710

[3]

Deregulation of microRNA involved in hematopoiesis and the immune response in HTLV-I adult T-cell leukemia [J].

Bellon, Marcia ;

Lepelletier, Yves ;

Hermine, Olivier ;

Nicot, Christophe .

BLOOD, 2009, 113 (20) :4914-4917

[4]

Expression of microRNA-146 suppresses NF-κB activity with reduction of metastatic potential in breast cancer cells [J].

Bhaumik, D. ;

Scott, G. K. ;

Schokrpur, S. ;

Patil, C. K. ;

Campisi, J. ;

Benz, C. C. .

ONCOGENE, 2008, 27 (42) :5643-5647

[5]

Narrowing and genomic annotation of the commonly deleted region of the 5q-syndrome [J].

Boultwood, J ;

Fidler, C ;

Strickson, AJ ;

Watkins, F ;

Gama, S ;

Kearney, L ;

Tosi, S ;

Kasprzyk, A ;

Cheng, JF ;

Jaju, RJ ;

Wainscoat, JS .

BLOOD, 2002, 99 (12) :4638-4641

[6]

Epstein-Barr virus latent membrane protein 1 induces cellular MicroRNA miR-146a, a modulator of lymphocyte signaling pathways [J].

Cameron, Jennifer E. ;

Yin, Qinyan ;

Fewell, Claire ;

Lacey, Michelle ;

McBride, Jane ;

Wang, Xia ;

Lin, Zhen ;

Schaefer, Brian C. ;

Flemington, Erik K. .

JOURNAL OF VIROLOGY, 2008, 82 (04) :1946-1958

[7]

MicroRNA-133 controls cardiac hypertrophy [J].

Care, Alessandra ;

Catalucci, Daniele ;

Felicetti, Federica ;

Bonci, Desiree ;

Addario, Antonio ;

Gallo, Paolo ;

Bang, Marie-Louise ;

Segnalini, Patrizia ;

Gu, Yusu ;

Dalton, Nancy D. ;

Elia, Leonardo ;

Latronico, Michael V. G. ;

Hoydal, Morten ;

Autore, Camillo ;

Russo, Matteo A. ;

Dorn, Gerald W., II ;

Ellingsen, Oyvind ;

Ruiz-Lozano, Pilar ;

Peterson, Kirk L. ;

Croce, Carlo M. ;

Peschle, Cesare ;

Condorelli, Gianluigi .

NATURE MEDICINE, 2007, 13 (05) :613-618

[8]

Contrast in Aberrant MicroRNA Expression in Systemic Lupus Erythematosus and Rheumatoid Arthritis: Is MicroRNA-146 All We Need? [J].

Chan, Edward K. L. ;

Satoh, Minoru ;

Pauley, Kaleb M. .

ARTHRITIS AND RHEUMATISM, 2009, 60 (04) :912-915

[9]

Characterization of microRNAs in serum: a novel class of biomarkers for diagnosis of cancer and other diseases [J].

Chen, Xi ;

Ba, Yi ;

Ma, Lijia ;

Cai, Xing ;

Yin, Yuan ;

Wang, Kehui ;

Guo, Jigang ;

Zhang, Yujing ;

Chen, Jiangning ;

Guo, Xing ;

Li, Qibin ;

Li, Xiaoying ;

Wang, Wenjing ;

Zhang, Yan ;

Wang, Jin ;

Jiang, Xueyuan ;

Xiang, Yang ;

Xu, Chen ;

Zheng, Pingping ;

Zhang, Juanbin ;

Li, Ruiqiang ;

Zhang, Hongjie ;

Shang, Xiaobin ;

Gong, Ting ;

Ning, Guang ;

Wang, Jun ;

Zen, Ke ;

Zhang, Junfeng ;

Zhang, Chen-Yu .

CELL RESEARCH, 2008, 18 (10) :997-1006

[10]

miR-145 and miR-143 regulate smooth muscle cell fate and plasticity [J].

Cordes, Kimberly R. ;

Sheehy, Neil T. ;

White, Mark P. ;

Berry, Emily C. ;

Morton, Sarah U. ;

Muth, Alecia N. ;

Lee, Ting-Hein ;

Miano, Joseph M. ;

Ivey, Kathryn N. ;

Srivastava, Deepak .

NATURE, 2009, 460 (7256) :705-U80

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