Membrane fusion induced by phospholipase C and sphingomyelinases

被引：51

作者：

Goñi, FM

Alonso, A

机构：

[1] Univ Basque Country, Unidad Biofis, CSIC, EHU, E-48080 Bilbao, Spain

[2] Univ Basque Country, Dept Bioquim, E-48080 Bilbao, Spain

来源：

BIOSCIENCE REPORTS | 2000年 / 20卷 / 06期

关键词：

phospholipase C; sphingomyelinase; membrane fusion; liposomes; model membranes; non-bilayer lipids; non-lamellar lipid phase;

D O I：

10.1023/A:1010450702670

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In the past decade lipid vesicle fusion induced by either bacterial PC-preferring phospholipase C, phosphatidylinositol-specific phospholipase C, sphingomyelinase, or a combination of phospholipase C and sphingomyelinase has been demonstrated. In the present paper, the experimental evidence is reviewed, and discussed in terms of the underlying molecular mechanisms of fusion, and of the possible physiological relevance of these findings.

引用

收藏

页码：443 / 463

页数：21

相关论文

共 74 条

[1] RAPID TRANSBILAYER DIFFUSION OF 1,2-DIACYLGLYCEROL AND ITS RELEVANCE TO CONTROL OF MEMBRANE CURVATURE [J].

ALLAN, D ;

THOMAS, P ;

MICHELL, RH .

NATURE, 1978, 276 (5685) :289-290

[2] LYSIS AND REASSEMBLY OF SONICATED LECITHIN VESICLES IN THE PRESENCE OF TRITON X-100 [J].

ALONSO, A ;

VILLENA, A ;

GONI, FM .

FEBS LETTERS, 1981, 123 (02) :200-204

[3] Dual inhibitory effect of gangliosides on phospholipase C-promoted fusion of lipidic vesicles [J].

Basanez, G ;

Fidelio, GD ;

Goni, FM ;

Maggio, B ;

Alonso, A .

BIOCHEMISTRY, 1996, 35 (23) :7506-7513

[4] Morphological changes induced by phospholipase C and by sphingomyelinase on large unilamellar vesicles: A cryo-transmission electron microscopy study of liposome fusion [J].

Basanez, G ;

RuizArguello, MB ;

Alonso, A ;

Goni, FM ;

Karlsson, G ;

Edwards, K .

BIOPHYSICAL JOURNAL, 1997, 72 (06) :2630-2637

[5] Diacylglycerol and the promotion of lamellar-hexagonal and lamellar-isotropic phase transitions in lipids: Implications for membrane fusion [J].

Basanez, G ;

Nieva, JL ;

Rivas, E ;

Alonso, A ;

Goni, FM .

BIOPHYSICAL JOURNAL, 1996, 70 (05) :2299-2306

[6] Effect of single chain lipids on phospholipase C-promoted vesicle fusion.: A test for the stalk hypothesis of membrane fusion [J].

Basáñez, G ;

Goñi, FM ;

Alonso, A .

BIOCHEMISTRY, 1998, 37 (11) :3901-3908

[7] Poly(ethylene glycol)-lipid conjugates inhibit phospholipase C-induced lipid hydrolysis, liposome aggregation and fusion through independent mechanisms [J].

Basanez, G ;

Goni, FM ;

Alonso, A .

FEBS LETTERS, 1997, 411 (2-3) :281-286

[8] LA-3+-INDUCED FUSION OF PHOSPHATIDYLSERINE LIPOSOMES - CLOSE APPROACH, INTERMEMBRANE INTERMEDIATES, AND THE ELECTROSTATIC SURFACE-POTENTIAL [J].

BENTZ, J ;

ALFORD, D ;

COHEN, J ;

DUZGUNES, N .

BIOPHYSICAL JOURNAL, 1988, 53 (04) :593-607

[9] PHOSPHOLIPASE-C ACTIVITY-INDUCED FUSION OF PURE LIPID MODEL MEMBRANES - A FREEZE-FRACTURE STUDY [J].

BURGER, KNJ ;

NIEVA, JL ;

ALONSO, A ;

VERKLEIJ, AJ .

BIOCHIMICA ET BIOPHYSICA ACTA, 1991, 1068 (02) :249-253

[10] LIPID SIGNALING ENZYMES AND SURFACE DILUTION KINETICS [J].

CARMAN, GM ;

DEEMS, RA ;

DENNIS, EA .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1995, 270 (32) :18711-18714

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