Membrane fusion induced by phospholipase C and sphingomyelinases

被引：51

作者：

Goñi, FM

Alonso, A

机构：

[1] Univ Basque Country, Unidad Biofis, CSIC, EHU, E-48080 Bilbao, Spain

[2] Univ Basque Country, Dept Bioquim, E-48080 Bilbao, Spain

来源：

BIOSCIENCE REPORTS | 2000年 / 20卷 / 06期

关键词：

phospholipase C; sphingomyelinase; membrane fusion; liposomes; model membranes; non-bilayer lipids; non-lamellar lipid phase;

D O I：

10.1023/A:1010450702670

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In the past decade lipid vesicle fusion induced by either bacterial PC-preferring phospholipase C, phosphatidylinositol-specific phospholipase C, sphingomyelinase, or a combination of phospholipase C and sphingomyelinase has been demonstrated. In the present paper, the experimental evidence is reviewed, and discussed in terms of the underlying molecular mechanisms of fusion, and of the possible physiological relevance of these findings.

引用

收藏

页码：443 / 463

页数：21

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