Hypoxia regulates macrophage functions in inflammation

被引:380
作者
Murdoch, C [1 ]
Muthana, M [1 ]
Lewis, CE [1 ]
机构
[1] Univ Sheffield, Sch Med, Henry Wellcome Labs Med REs, Acad Unit Pathol,Div Genom Med,Targeting Grp, Sheffield S10 2RX, S Yorkshire, England
关键词
D O I
10.4049/jimmunol.175.10.6257
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
The presence of areas of hypoxia is a prominent feature of various inflamed, diseased tissues, including malignant tumors, atherosclerotic plaques, myocardial infarcts, the synovia of joints with rheumatoid arthritis, healing wounds, and sites of bacterial infection. These areas form when the blood supply is occluded and/or unable to keep pace with the growth and/or infiltration of inflammatory cells in a given area. Macrophages are present in all tissues of the body where they normally assist in guarding against invading pathogens and re late normal cell turnover and tissue remodeling. However, they are also known to accumulate in large numbers in such ischemic/hypoxic sites. Recent studies show that macrophages then respond rapidly to the hypoxia present by altering their expression Of a wide array of genes. In the present study, we outline and compare the phenotypic responses of macrophages to hypoxia in different diseased states and the implications of these for their progression and treatment.
引用
收藏
页码:6257 / 6263
页数:7
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