Control of fuzzy discrete event systems and its applications to clinical treatment planning

被引：21

作者：

Lin, F ^{[1
]}

Ying, H ^{[1
]}

Luan, X ^{[1
]}

MacArthur, RD ^{[1
]}

Cohn, JA ^{[1
]}

Barth-Jones, D ^{[1
]}

Crane, LR ^{[1
]}

机构：

[1] Wayne State Univ, Dept Elect & Comp Engn, Detroit, MI 48202 USA

来源：

2004 43RD IEEE CONFERENCE ON DECISION AND CONTROL (CDC), VOLS 1-5 | 2004年

关键词：

discrete event systems; optimal control; fuzzy logic; decision-making; treatment planning; AIDS; HIV;

D O I：

10.1109/CDC.2004.1428683

中图分类号：

TP [自动化技术、计算机技术];

学科分类号：

0812 ;

摘要：

In this paper, we further develop a modeling and control approach to fuzzy discrete event systems that we initially proposed in [LY01, LY02]. We first investigate an optimal control problem in fuzzy discrete event systems. The problem is abstracted from real applications in biomedical fields. The control objective is to maximize a treatment effectiveness measure while keeping some cost below a given level. This problem is difficult because both the effectiveness function and the cost function are state dependent and hence are not monotonic. Furthermore, the state space of a fuzzy discrete event system is infinite in general. We develop an online approach that can solve this problem. We then apply this approach to HIV/AIDS treatment planning, because it is one of the most difficult treatments in medicine. We also develop a novel computerized treatment decision-making system based on the optimal control approach. The preliminary statistic evaluation of our system shows a strong agreement between the physicians and our system in terms of which treatment regimens to be used for patients of various conditions.

引用

页码：519 / 524

页数：6

共 23 条

[1]

Agresti A., 1990, Analysis of categorical data

[2] SUPERVISORY CONTROL OF A RAPID THERMAL MULTIPROCESSOR [J].

BALEMI, S ;

HOFFMANN, GJ ;

GYUGYI, P ;

WONGTOI, H ;

FRANKLIN, GF .

IEEE TRANSACTIONS ON AUTOMATIC CONTROL, 1993, 38 (07) :1040-1059

[3]

BENHADJALOUANE N, IN PRESS IEEE T AUTO

[4] The real-time supervisory control of an experimental manufacturing cell [J].

Brandin, BA .

IEEE TRANSACTIONS ON ROBOTICS AND AUTOMATION, 1996, 12 (01) :1-14

[5]

Cassandras C.G., 2021, Introduction to Discrete Event Systems, V3rd

[6] LIMITED LOOKAHEAD POLICIES IN SUPERVISORY CONTROL OF DISCRETE EVENT SYSTEMS [J].

CHUNG, SL ;

LAFORTUNE, S ;

LIN, F .

IEEE TRANSACTIONS ON AUTOMATIC CONTROL, 1992, 37 (12) :1921-1935

[7]

CHUNG SL, 1994, DISCRETE EVENT DYN S, V4, P237

[8]

Heymann M., 1994, Discrete Event Dynamic Systems: Theory & Applications, V4, P221, DOI 10.1007/BF01438708

[9] MODELING AND ANALYSIS OF TRANSACTION EXECUTION IN DATABASE-SYSTEMS [J].

LAFORTUNE, S .

IEEE TRANSACTIONS ON AUTOMATIC CONTROL, 1988, 33 (05) :439-447

[10] AN INTEGRATED INFORMATION-SYSTEM FOR THE INTERVENTION AND PREVENTION OF AIDS [J].

LI, LX ;

XU, LD .

INTERNATIONAL JOURNAL OF BIO-MEDICAL COMPUTING, 1991, 29 (3-4) :191-206

← 1 2 3 →