Does CDP-choline modulate phospholipase activities after transient forebrain ischemia?

被引：40

作者：

Rao, AM

Hatcher, JF

Dempsey, RJ

机构：

[1] Univ Wisconsin, Dept Neurol Surg, Ctr Clin Sci, Madison, WI 53792 USA

[2] Univ Wisconsin, Cardiovasc Res Ctr, Madison, WI 53792 USA

[3] Vet Adm Hosp, Madison, WI USA

来源：

BRAIN RESEARCH | 2001年 / 893卷 / 1-2期

关键词：

arachidonic acid; apoptosis; cardiolipin; citicoline; lysophospholipids; mitochondria; neuronal death; phosphatidylcholine; phosphatidylinositol; phospholipase A(2);

D O I：

10.1016/S0006-8993(00)03280-7

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Ten min forebrain ischemia/1-day reperfusion resulted in significant decreases in total phosphatidylcholine (PtdCho), phosphatidylinositol (PtdIns), and cardiolipin in gerbil hippocampus. CDP-choline restored cardiolipin levels, arachidonic acid content of PtdCho, partially but significantly restored total PtdCho, and had no effect on PtdIns. These data suggest that CDP-choline prevented the activation of phospholipase A(2) (rather than inhibiting phospholipase A(2) activity) but did not affect activities: of PtdCho-phospholipases C and/or D, or phosphoinositide-phospholipase C. CDP-choline also provided significant protection for hippocampal CA(1) neurons. (C) 2001 Elsevier Science B.V. All rights reserved.

引用

页码：268 / 272

页数：5

共 40 条

[1] EFFECTS OF CDP-CHOLINE ON PHOSPHOLIPASE-A2 AND CHOLINEPHOSPHOTRANSFERASE ACTIVITIES FOLLOWING A CRYOGENIC BRAIN INJURY IN THE RABBIT [J].