Baylis-Hillman reaction;
heterocycles;
Lewis bases;
titanium;
D O I:
10.1002/anie.200352233
中图分类号:
O6 [化学];
学科分类号:
0703 ;
摘要:
A key role for sulfur and the potential for Nax→P intrabridgehead interactions are invoked to explain the impressive effect of the cocatalyst (shown in color) in the TiCl4-mediated Baylis-Hillman reaction [Eq. (1)]. Even sterically hindered and electronically deactivated aldehydes such as o-anisaldehyde can be coupled under these conditions. EWG = electron-withdrawing group, RT= room temperature.