A highly active and selective catalyst system for the Baylis-Hillman reaction

被引：56

作者：

You, JS ^{[1
]}

Xu, JH ^{[1
]}

Verkade, JG ^{[1
]}

机构：

[1] Iowa State Univ, Dept Chem, Ames, IA 50011 USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2003年 / 42卷 / 41期

关键词：

Baylis-Hillman reaction; heterocycles; Lewis bases; titanium;

D O I：

10.1002/anie.200352233

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A key role for sulfur and the potential for Nax→P intrabridgehead interactions are invoked to explain the impressive effect of the cocatalyst (shown in color) in the TiCl4-mediated Baylis-Hillman reaction [Eq. (1)]. Even sterically hindered and electronically deactivated aldehydes such as o-anisaldehyde can be coupled under these conditions. EWG = electron-withdrawing group, RT= room temperature.

引用

页码：5054 / 5056

页数：3

共 38 条

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