Perils and pitfalls in the interpretation of clinical trials: A reflection on the recent experience in multiple sclerosis

被引：31

作者：

Goodin, DS ^{[1
]}

机构：

[1] Univ Calif San Francisco, Dept Neurol, San Francisco, CA 94143 USA

来源：

NEUROEPIDEMIOLOGY | 1999年 / 18卷 / 02期

关键词：

multiple sclerosis; clinical trials; cladribine; interferon beta; optic neuritis;

D O I：

10.1159/000069408

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

Therapeutic trials in multiple sclerosis, in part because of the marked intra- and interindividual variability of its clinical course, are prone to serious flaws in both design and interpretation. As a consequence, it has been a common historical pattern that treatment regimens, which are enthusiastically recommended at one point in time, are later proven to be ineffective by more definitive studies. This review considers several recently published therapeutic trials in order to exemplify some of the difficulties that commonly arise in this area of clinical research.

引用

页码：53 / 63

页数：11

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