Microbial genome mining answers longstanding biosynthetic questions

被引:7
作者
Crawford, Jason M. [2 ]
Clardy, Jon [1 ]
机构
[1] Harvard Univ, Sch Med, Dept Biol Chem & Mol Pharmacol, Boston, MA 02215 USA
[2] Yale Univ, Dept Chem, Inst Biol Chem, New Haven, CT 06520 USA
关键词
METABOLITE; MECHANISM; ACID;
D O I
10.1073/pnas.1205361109
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
引用
收藏
页码:7589 / 7590
页数:2
相关论文
共 16 条
  • [1] Characterisation of 3-methylorcinaldehyde synthase (MOS) in Acremonium strictum:: first observation of a reductive release mechanism during polyketide biosynthesis
    Bailey, Andrew M.
    Cox, Russell J.
    Harley, Kate
    Lazarus, Colin M.
    Simpson, Thomas J.
    Skellam, Elizabeth
    [J]. CHEMICAL COMMUNICATIONS, 2007, (39) : 4053 - 4055
  • [2] A fresh look at natural tropolonoids
    Bentley, Ronald
    [J]. NATURAL PRODUCT REPORTS, 2008, 25 (01) : 118 - 138
  • [3] Metagenomic approaches to natural products from free-living and symbiotic organisms
    Brady, Sean F.
    Simmons, Luke
    Kim, Jeffrey H.
    Schmidt, Eric W.
    [J]. NATURAL PRODUCT REPORTS, 2009, 26 (11) : 1488 - 1503
  • [4] STIPITATONIC ACID BIOSYNTHESIS - INCORPORATION OF "[FORMYL-C-14]-3-METHYLORCYLALDEHYDE AND [C-14]STIPITALDEHYDIC ACID, A NEW TROPOLONE METABOLITE
    BRYANT, RW
    LIGHT, RJ
    [J]. BIOCHEMISTRY, 1974, 13 (07) : 1516 - 1522
  • [5] New insights into the formation of fungal aromatic polyketides
    Crawford, Jason M.
    Townsend, Craig A.
    [J]. NATURE REVIEWS MICROBIOLOGY, 2010, 8 (12) : 879 - 889
  • [6] Genetic, molecular, and biochemical basis of fungal tropolone biosynthesis
    Davison, Jack
    al Fahad, Ahmed
    Cai, Menghao
    Song, Zhongshu
    Yehia, Samar Y.
    Lazarus, Colin M.
    Bailey, Andrew M.
    Simpson, Thomas J.
    Cox, Russell J.
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2012, 109 (20) : 7642 - 7647
  • [7] Catalytic role of the C-terminal domains of a fungal non-reducing polyketide synthase
    Fisch, Katja M.
    Skellam, Elizabeth
    Ivison, David
    Cox, Russell J.
    Bailey, Andrew M.
    Lazarus, Colin M.
    Simpson, Thomas J.
    [J]. CHEMICAL COMMUNICATIONS, 2010, 46 (29) : 5331 - 5333
  • [8] Genomics of secondary metabolite production by Pseudomonas spp
    Gross, Harald
    Loper, Joyce E.
    [J]. NATURAL PRODUCT REPORTS, 2009, 26 (11) : 1408 - 1446
  • [9] Mining cyanobacterial genomes for genes encoding complex biosynthetic pathways
    Kalaitzis, John A.
    Lauro, Federico M.
    Neilan, Brett A.
    [J]. NATURAL PRODUCT REPORTS, 2009, 26 (11) : 1447 - 1465
  • [10] Genomic basis for natural product biosynthetic diversity in the actinomycetes
    Nett, Markus
    Ikeda, Haruo
    Moore, Bradley S.
    [J]. NATURAL PRODUCT REPORTS, 2009, 26 (11) : 1362 - 1384