Humanized mice as a preclinical tool for infectious disease and biomedical research

被引：45

作者：

Shultz, Leonard D. ^{[1
]}

Brehm, Michael A. ^{[2
]}

Bavari, Sina ^{[3
]}

Greiner, Dale L. ^{[2
]}

机构：

[1] Jackson Lab, Bar Harbor, ME 04609 USA

[2] Univ Massachusetts, Sch Med, Worcester, MA USA

[3] USAMRIID, Ft Detrick, MD USA

来源：

ANIMAL MODELS: THEIR VALUE IN PREDICTING DRUG EFFICACY AND TOXICITY | 2011年 / 1245卷

基金：

美国国家卫生研究院;

关键词：

SCID; humanized mice; immunity; infectious disease; NSG; RESTRICTED IMMUNE-RESPONSES; SCID IL2R-GAMMA(NULL) MICE; MOUSE MODEL; CELLS;

D O I：

10.1111/j.1749-6632.2011.06310.x

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Immunodeficient mice bearing an IL2r gamma(null) mutation permit engraftment of a functional human immune system and study of human-specific infectious agents that was not previously possible.

引用

页码：50 / 54

页数：5

共 10 条

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