Regulation by calcium of the synthesis of 1,25-dihydroxyvitamin D3 and 24,25-dihydroxyvitamin D3 in Walker 256 carcinosarcoma cells:: comparison with synthesis regulation from renal phenotype cells (LLC-PK1)

被引：1

作者：

del Campo, MJM ^{[1
]}

Villameytide, MLT ^{[1
]}

机构：

[1] Fdn Jimenez Diaz, Lab Bioquim, Secc Metab Mineral & Oseo, E-28040 Madrid, Spain

来源：

CANCER LETTERS | 1998年 / 134卷 / 02期

关键词：

Walker 256 carcinosarcoma cells; LLC-PK1; cells; 1,25-dihydroxyvitamin D-3; 24,25-dihydroxyvitamin D-3; calcium;

D O I：

10.1016/S0304-3835(98)00245-6

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The aim of this work was to study the regulation by calcium of the synthesis of 1,25-dihydroxyvitamin D-3 (1,25(OH)(2)D-3) and 24,25-dihydroxyvitamin D-3 (24,25(OH)(2)D-3) in Walker 256 carcinosarcoma (W-256) cells compared to renal phenotype LLC-PK1 cells. We have detected synthesis of 1,25(OH)(2)D-3 and 24,25(OH)(2)D-3 in W-256 cells. Levels of 1,25(OH)(2)D-3 in W-256 were similar to those of LLC-PK1 cells. Levels of 24,25(OH)(2)D-3 were higher in W-256 than in LLC-PK1 cells. High levels of calcium inhibited 1,25(OH)(2)D-3 synthesis in LLC-PK1 cells but not in W-256 cells. (C) 1998 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：147 / 153

页数：7

共 41 条

[11] RAT PLASMA 25-HYDROXYVITAMIN D3 BINDING-PROTEIN - INHIBITOR OF 25-HYDROXYVITAMIN D3-1-ALPHA-HYDROXYLASE [J].

GHAZARIAN, JG ;

KREAM, B ;

BOTHAM, KM ;

NICKELLS, MW ;

DELUCA, HF .

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 1978, 189 (01) :212-220

[12] INHIBITION OF 25-HYDROXYVITAMIN-D 1-ALPHA-HYDROXYLASE BY RENAL MITOCHONDRIAL PROTEIN KINASE-CATALYZED PHOSPHORYLATION [J].

GHAZARIAN, JG ;

YANDA, DM .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1985, 132 (03) :1095-1102

[13] MECHANISM OF 25-HYDROXYCHOLECALCIFEROL 1-ALPHA-HYDROXYLATION - INCORPORATION OF OXYGEN-18 INTO 1-ALPHA POSITION OF 25-HYDROXYCHOLECALCIFEROL [J].

GHAZARIAN, JG ;

SCHNOES, HK ;

DELUCA, HF .

BIOCHEMISTRY, 1973, 12 (14) :2555-2558

[14]

GHAZARIAN JG, 1990, J BONE MINER RES, V5, P897

[15]

GRAY RW, 1972, J BIOL CHEM, V247, P7528

[16]

GRYNKIEWICZ G, 1985, J BIOL CHEM, V260, P3440

[17] VITAMIN-D HYDROXYLASES [J].

HENRY, HL .

JOURNAL OF CELLULAR BIOCHEMISTRY, 1992, 49 (01) :4-9

[18] INFLUENCE OF A TUMOR PROMOTING PHORBOL ESTER ON THE METABOLISM OF 25-HYDROXYVITAMIN-D3 [J].

HENRY, HL .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1986, 139 (02) :495-500

[19] INTERACTIONS BETWEEN INTRACELLULAR SIGNALS INVOLVED IN THE REGULATION OF 25-HYDROXYVITAMIN-D3 METABOLISM [J].

HENRY, HL ;

LUNTAO, EM .

ENDOCRINOLOGY, 1989, 124 (05) :2228-2234

[20] SIMILARITY OF SYNTHETIC PEPTIDE FROM HUMAN-TUMOR TO PARATHYROID-HORMONE INVIVO AND INVITRO [J].

HORIUCHI, N ;

CAULFIELD, MP ;

FISHER, JE ;

GOLDMAN, ME ;

MCKEE, RL ;

REAGAN, JE ;

LEVY, JJ ;

NUTT, RF ;

RODAN, SB ;

SCHOFIELD, TL ;

CLEMENS, TL ;

ROSENBLATT, M .

SCIENCE, 1987, 238 (4833) :1566-1568

← 1 2 3 4 5 →