Efficient total synthesis of pentosidine, an advanced glycation endproduct

被引：18

作者：

Sugiyama, H

Yokokawa, F

Shioiri, T ^{[1
]}

Katagiri, N

Oda, O

Ogawa, H

机构：

[1] Nagoya City Univ, Fac Pharmaceut Sci, Mizuho Ku, Nagoya, Aichi 4678603, Japan

[2] Biodynam Res Inst, Mizuho Ku, Nagoya, Aichi 4678633, Japan

[3] Shinseikai Dai Ichi Hosp, Mizuho Ku, Nagoya, Aichi 4678633, Japan

来源：

TETRAHEDRON LETTERS | 1999年 / 40卷 / 13期

关键词：

pentosidine; an advanced glycation endproduct; asymmetric synthesis; cyclization; amino acids and derivatives;

D O I：

10.1016/S0040-4039(99)00204-X

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The efficient total synthesis of pentosidine (1), an advanced glycation endproduct, was achieved using the asymmetric alkylation of a chiral schiff base (2), the intramolecular guanylation with mercury (II) chloride, and the quaternization accompanied by removal of the trityl group as key steps. (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

页码：2569 / 2572

页数：4

共 13 条

[1] INCREASED COLLAGEN-LINKED PENTOSIDINE LEVELS AND ADVANCED GLYCOSYLATION END-PRODUCTS IN EARLY DIABETIC NEPHROPATHY [J].