NFATc2 and NFATc3 transcription factors play a crucial role in suppression of CD4+ T lymphocytes by CD4+ CD25+ regulatory T cells

被引:112
作者
Bopp, T
Palmetshofer, A
Serfling, E
Heib, V
Schmitt, S
Richter, C
Klein, M
Schild, H
Schmitt, E
Stassen, M
机构
[1] Johannes Gutenberg Univ Mainz, Inst Immunol, D-55131 Mainz, Germany
[2] Johannes Gutenberg Univ Mainz, Ctr Nat Sci & Med, D-55131 Mainz, Germany
[3] Univ Wurzburg, Inst Pathol, Dept Mol Pathol, D-97080 Wurzburg, Germany
关键词
D O I
10.1084/jem.20041538
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
The phenotype of NFATc2(-/-) c3(-/-) (double knockout [DKO]) mire implies a disturbed regulation of T cell responses, evidenced by massive lymphadenopathy, splenomegaly, and autoaggressive phenomena. The population of CD4(+) CD25(+) T cells from DKO mire lacks regulatory capacity, except a small subpopulation that highly expresses glucocorticoid-induced tumor necrosis factor receptor family-related gene (GITR) and CD25. However, neither wild-type nor DKO CD4(+) CD25(+) regulatory T cells (T reg cells) are able to suppress proliferation of DKO CD4(+) CD25(-) T helper cells. Therefore, combined NFATc2/c3 deficiency is compatible with the development of CD4(+) CD25(+) T reg cells but renders conventional CD4(+) T cells unresponsive to suppression, underlining the importance of NFAT proteins for sustaining T cell homeostasis.
引用
收藏
页码:181 / 187
页数:7
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