Exploiting the potential of antisense: Beyond phosphorothioate oligodeoxynucleotides

被引：57

作者：

Stein, CA

机构：

来源：

CHEMISTRY & BIOLOGY | 1996年 / 3卷 / 05期

关键词：

D O I：

10.1016/S1074-5521(96)90113-1

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Phosphorothioate oligodeoxynucleotides, designed as nuclease-resistant antisense agents, appear to have a number of surprising biological effects that are unrelated to their intended antisense activity. These effects may be useful in themselves, but must be understood for the full potential of antisense technology to be realized.

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页码：319 / 323

页数：5

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