Exploiting the potential of antisense: Beyond phosphorothioate oligodeoxynucleotides

被引:57
作者
Stein, CA
机构
来源
CHEMISTRY & BIOLOGY | 1996年 / 3卷 / 05期
关键词
D O I
10.1016/S1074-5521(96)90113-1
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Phosphorothioate oligodeoxynucleotides, designed as nuclease-resistant antisense agents, appear to have a number of surprising biological effects that are unrelated to their intended antisense activity. These effects may be useful in themselves, but must be understood for the full potential of antisense technology to be realized.
引用
收藏
页码:319 / 323
页数:5
相关论文
共 23 条
[11]  
LAPLANCHE LA, 1986, NUCL AICDSRES, V17, P1549
[12]   SEQUENCE CONTEXT OF ANTISENSE RELA/NF-KAPPA-B PHOSPHOROTHIOATES DETERMINES SPECIFICITY [J].
MALTESE, JY ;
SHARMA, HW ;
VASSILEV, L ;
NARAYANAN, R .
NUCLEIC ACIDS RESEARCH, 1995, 23 (07) :1146-1151
[13]  
METHIA N, 1993, BLOOD, V82, P1395
[14]   TRANSPORT OF PHOSPHOROTHIOATE OLIGONUCLEOTIDES IN KIDNEY - IMPLICATIONS FOR MOLECULAR THERAPY [J].
RAPPAPORT, J ;
HANSS, B ;
KOPP, JB ;
COPELAND, TD ;
BRUGGEMAN, LA ;
COFFMAN, TM ;
KLOTMAN, PE .
KIDNEY INTERNATIONAL, 1995, 47 (05) :1462-1469
[15]   ANTISENSE C-MYB OLIGONUCLEOTIDES INHIBIT INTIMAL ARTERIAL SMOOTH-MUSCLE CELL ACCUMULATION INVIVO [J].
SIMONS, M ;
EDELMAN, ER ;
DEKEYSER, JL ;
LANGER, R ;
ROSENBERG, RD .
NATURE, 1992, 359 (6390) :67-70
[16]   AUTOMATED SOLID-PHASE SYNTHESIS, SEPARATION, AND STEREOCHEMISTRY OF PHOSPHOROTHIOATE ANALOGS OF OLIGODEOXYRIBONUCLEOTIDES [J].
STEC, WJ ;
ZON, G ;
EGAN, W ;
STEC, B .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1984, 106 (20) :6077-6079
[17]   NOVEL ROUTE TO OLIGO(DEOXYRIBONUCLEOSIDE PHOSPHOROTHIOATES) - STEREOCONTROLLED SYNTHESIS OF P-CHIRAL OLIGO(DEOXYRIBONUCLEOSIDE PHOSPHOROTHIOATES) [J].
STEC, WJ ;
GRAJKOWSKI, A ;
KOZIOLKIEWICZ, M ;
UZNANSKI, B .
NUCLEIC ACIDS RESEARCH, 1991, 19 (21) :5883-5888
[18]  
Stein C A, 1993, Antisense Res Dev, V3, P19
[19]   PHYSICOCHEMICAL PROPERTIES OF PHOSPHOROTHIOATE OLIGODEOXYNUCLEOTIDES [J].
STEIN, CA ;
SUBASINGHE, C ;
SHINOZUKA, K ;
COHEN, JS .
NUCLEIC ACIDS RESEARCH, 1988, 16 (08) :3209-3221
[20]   ANTISENSE OLIGONUCLEOTIDES AS THERAPEUTIC AGENTS - IS THE BULLET REALLY MAGICAL [J].
STEIN, CA ;
CHENG, YC .
SCIENCE, 1993, 261 (5124) :1004-1012