The production of recombinant pharmaceutical proteins in plants

被引:592
作者
Ma, JKC
Drake, PMW
Christou, P
机构
[1] St George Hosp, Sch Med, Dept Infect Dis, London SW17 0RE, England
[2] Fraunhofer Inst Mol Biol & Appl Ecol, D-57392 Schmallenberg, Germany
关键词
D O I
10.1038/nrg1177
中图分类号
Q3 [遗传学];
学科分类号
071007 ; 090102 ;
摘要
Imagine a world in which any protein, either naturally occurring or designed by man, could be produced safely, inexpensively and in almost unlimited quantities using only simple nutrients, water and sunlight. This could one day become reality as we learn to harness the power of plants for the production of recombinant proteins on an agricultural scale. Molecular farming in plants has already proven to be a successful way of producing a range of technical proteins. The first plant-derived recombinant pharmaceutical proteins are now approaching commercial approval, and many more are expected to follow.
引用
收藏
页码:794 / 805
页数:12
相关论文
共 113 条
  • [1] A viral suppressor of gene silencing in plants
    Anandalakshmi, R
    Pruss, GJ
    Ge, X
    Marathe, R
    Mallory, AC
    Smith, TH
    Vance, VB
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (22) : 13079 - 13084
  • [2] Potato tubers as a biofactory for recombinant antibodies
    Artsaenko, O
    Kettig, B
    Fiedler, U
    Conrad, U
    During, K
    [J]. MOLECULAR BREEDING, 1998, 4 (04) : 313 - 319
  • [3] Galactose-extended glycans of antibodies produced by transgenic plants
    Bakker, H
    Bardor, M
    Molthoff, JW
    Gomord, V
    Elbers, I
    Stevens, LH
    Jordi, W
    Lommen, A
    Faye, L
    Lerouge, P
    Bosch, D
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2001, 98 (05) : 2899 - 2904
  • [4] Immunoreactivity in mammals of two typical plant glyco-epitopes, core α(1,3)-fucose and core xylose
    Bardor, M
    Faveeuw, C
    Fitchette, AC
    Gilbert, D
    Galas, L
    Trottein, F
    Faye, L
    Lerouge, P
    [J]. GLYCOBIOLOGY, 2003, 13 (06) : 427 - 434
  • [5] THE EXPRESSION OF A NOPALINE SYNTHASE - HUMAN GROWTH-HORMONE CHIMERIC GENE IN TRANSFORMED TOBACCO AND SUNFLOWER CALLUS-TISSUE
    BARTA, A
    SOMMERGRUBER, K
    THOMPSON, D
    HARTMUTH, K
    MATZKE, MA
    MATZKE, AJM
    [J]. PLANT MOLECULAR BIOLOGY, 1986, 6 (05) : 347 - 357
  • [6] Efficient chemoenzymatic synthesis of O-linked sialyl oligosaccharides
    Blixt, O
    Allin, K
    Pereira, L
    Datta, A
    Paulson, JC
    [J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2002, 124 (20) : 5739 - 5746
  • [7] Production of recombinant proteins in plant root exudates
    Borisjuk, NV
    Borisjuk, LG
    Logendra, S
    Petersen, F
    Gleba, Y
    Raskin, I
    [J]. NATURE BIOTECHNOLOGY, 1999, 17 (05) : 466 - 469
  • [8] Re-engineering plant gene targeting
    Britt, AB
    May, GD
    [J]. TRENDS IN PLANT SCIENCE, 2003, 8 (02) : 90 - 95
  • [9] Therapeutic antibody expression technology
    Chadd, HE
    Chamow, SM
    [J]. CURRENT OPINION IN BIOTECHNOLOGY, 2001, 12 (02) : 188 - 194
  • [10] A murine monoclonal antibody produced in transgenic plants with plant-specific glycans is not immunogenic in mice
    Chargelegue, D
    Vine, ND
    van Dolleweerd, CJ
    Drake, PMW
    Ma, JKC
    [J]. TRANSGENIC RESEARCH, 2000, 9 (03) : 187 - 194