Stem cells for the treatment of spinal cord injury

被引：117

作者：

Coutts, Margaret ^{[1
]}

Keirstead, Hans S. ^{[1
]}

机构：

[1] Univ Calif Irvine, Coll Med,Gillespie Neurosci Res Facil 2111, Dept Anat & Neurobiol, Stem Cell Res Ctr,Reeve Irvine Res Ctr, Irvine, CA 92717 USA

来源：

EXPERIMENTAL NEUROLOGY | 2008年 / 209卷 / 02期

关键词：

human embryonic stem cell; neural stem cell; bone marrow stem cell; differentiation; clinical trial; regulatory;

D O I：

10.1016/j.expneurol.2007.09.002

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

This article reviews stem cell-based strategies for spinal cord injury repair, and practical issues concerning their translation to the clinic. Recent progress in the stem cell field includes clinically compliant culture conditions and directed differentiation of both embryonic stem cells and somatic stem cells. We provide a brief overview of the types of stem cells under evaluation, comparing their advantages and disadvantages for use in human clinical trials. We review the practical considerations and risks that must be addressed before human treatments can begin. With a growing, understanding of these practical issues, stem cell biology, and spinal cord injury pathophysiology, stem cell-based therapies are moving closer to clinical application. (C) 2007 Elsevier Inc. All rights reserved.

引用

页码：368 / 377

页数：10

共 108 条

[1] Human mesenchymal stem cells modulate allogeneic immune cell responses [J].